Assay Detail
Binding
CHEMBL861242
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]DOI from human recombinant 5HT2A receptor expressed in CHO cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of novel hexahydro-pyrido[3',2':4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT(2C) receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.88 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190699 | — | — | 1 | 8.59 |
| CHEMBL191054 | — | — | 1 | 7.72 |
| CHEMBL203230 | — | — | 1 | 7.38 |
| CHEMBL206333 | — | — | 1 | 7.37 |
| CHEMBL203393 | — | — | 1 | 7.28 |
| CHEMBL203396 | — | — | 1 | 7.27 |
| CHEMBL383694 | — | — | 1 | 7.24 |
| CHEMBL206394 | — | — | 1 | 7.19 |
| CHEMBL203013 | — | — | 1 | 7.13 |
| CHEMBL206845 | — | — | 1 | 6.87 |
| CHEMBL203025 | — | — | 1 | 6.66 |
| CHEMBL382618 | — | — | 1 | 6.41 |
| CHEMBL205671 | — | — | 1 | 6.29 |
| CHEMBL383051 | — | — | 1 | 6.25 |
| CHEMBL206386 | — | — | 1 | 6.03 |
| CHEMBL206618 | — | — | 1 | 5.62 |
| CHEMBL202795 | — | — | 1 | 5.59 |
| CHEMBL382471 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190699 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL191054 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL203230 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL206333 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL203393 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL203396 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL383694 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL206394 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL203013 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL206845 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL203025 | — | Ki | = | 217.0 | nM | 6.66 |
| CHEMBL382618 | — | Ki | = | 392.0 | nM | 6.41 |
| CHEMBL205671 | — | Ki | = | 511.0 | nM | 6.29 |
| CHEMBL383051 | — | Ki | = | 565.0 | nM | 6.25 |
| CHEMBL206386 | — | Ki | = | 942.0 | nM | 6.03 |
| CHEMBL206618 | — | Ki | = | 2385.0 | nM | 5.62 |
| CHEMBL202795 | — | Ki | = | 2547.0 | nM | 5.59 |
| CHEMBL382471 | — | Ki | - | — | - |