Assay Detail
Binding
CHEMBL861244
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]5HT from human recombinant 5HT2C receptor expressed in CHO cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of novel hexahydro-pyrido[3',2':4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT(2C) receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 7.95 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190699 | — | — | 1 | 9.52 |
| CHEMBL203393 | — | — | 1 | 9.10 |
| CHEMBL203230 | — | — | 1 | 8.80 |
| CHEMBL191054 | — | — | 1 | 8.72 |
| CHEMBL206394 | — | — | 1 | 8.64 |
| CHEMBL206845 | — | — | 1 | 8.57 |
| CHEMBL203013 | — | — | 1 | 8.44 |
| CHEMBL206333 | — | — | 1 | 7.85 |
| CHEMBL383051 | — | — | 1 | 7.80 |
| CHEMBL383694 | — | — | 1 | 7.68 |
| CHEMBL382618 | — | — | 1 | 7.41 |
| CHEMBL203396 | — | — | 1 | 7.28 |
| CHEMBL206386 | — | — | 1 | 7.27 |
| CHEMBL202795 | — | — | 1 | 7.22 |
| CHEMBL206618 | — | — | 1 | 7.03 |
| CHEMBL205671 | — | — | 1 | 6.98 |
| CHEMBL203025 | — | — | 1 | 6.88 |
| CHEMBL382471 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190699 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL203393 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL203230 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL191054 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL206394 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL206845 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL203013 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL206333 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL383051 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL383694 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL382618 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL203396 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL206386 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL202795 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL206618 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL205671 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL203025 | — | Ki | = | 131.0 | nM | 6.88 |
| CHEMBL382471 | — | Ki | - | — | - |