Assay Detail
Functional
CHEMBL861290
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [35S]GTP-gamma-S binding to human delta opioid receptor expressed in CHO cells
33
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 8.12 | 9.28 |
| Emax | 11 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408889 | — | — | 3 | 9.28 |
| CHEMBL200199 | BIPHALIN | — | 3 | 8.96 |
| CHEMBL412331 | — | — | 3 | 8.89 |
| CHEMBL31421 | — | — | 3 | 8.80 |
| CHEMBL438739 | — | — | 3 | 8.25 |
| CHEMBL375412 | — | — | 3 | 8.03 |
| CHEMBL374325 | — | — | 3 | 7.60 |
| CHEMBL405192 | — | — | 3 | 7.57 |
| CHEMBL408832 | — | — | 3 | 7.57 |
| CHEMBL442483 | — | — | 3 | 7.27 |
| CHEMBL413644 | — | — | 3 | 7.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408889 | — | EC50 | = | 0.53 | nM | 9.28 |
| CHEMBL408889 | — | EC50 | = | 0.5248 | nM | 9.28 |
| CHEMBL200199 | BIPHALIN | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL200199 | BIPHALIN | EC50 | = | 1.122 | nM | 8.95 |
| CHEMBL412331 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL412331 | — | EC50 | = | 1.318 | nM | 8.88 |
| CHEMBL31421 | — | EC50 | = | 1.585 | nM | 8.80 |
| CHEMBL31421 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL438739 | — | EC50 | = | 5.6 | nM | 8.25 |
| CHEMBL438739 | — | EC50 | = | 5.623 | nM | 8.25 |
| CHEMBL375412 | — | EC50 | = | 9.4 | nM | 8.03 |
| CHEMBL375412 | — | EC50 | = | 9.333 | nM | 8.03 |
| CHEMBL374325 | — | EC50 | = | 25.12 | nM | 7.60 |
| CHEMBL374325 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL408832 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL405192 | — | EC50 | = | 26.92 | nM | 7.57 |
| CHEMBL405192 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL408832 | — | EC50 | = | 27.54 | nM | 7.56 |
| CHEMBL442483 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL442483 | — | EC50 | = | 54.95 | nM | 7.26 |
| CHEMBL413644 | — | EC50 | = | 74.0 | nM | 7.13 |
| CHEMBL413644 | — | EC50 | = | 74.13 | nM | 7.13 |
| CHEMBL408832 | — | Emax | = | 25.0 | % | - |
| CHEMBL413644 | — | Emax | = | 100.0 | % | - |
| CHEMBL438739 | — | Emax | = | 61.0 | % | - |
| CHEMBL200199 | BIPHALIN | Emax | = | 83.0 | % | - |
| CHEMBL31421 | — | Emax | = | 69.0 | % | - |
| CHEMBL375412 | — | Emax | = | 65.0 | % | - |
| CHEMBL412331 | — | Emax | = | 81.0 | % | - |
| CHEMBL408889 | — | Emax | = | 70.0 | % | - |
| CHEMBL405192 | — | Emax | = | 54.0 | % | - |
| CHEMBL374325 | — | Emax | = | 120.0 | % | - |
| CHEMBL442483 | — | Emax | = | 72.0 | % | - |