Assay Detail
Binding
CHEMBL861323
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PKA at 5 uM ATP
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
cAMP-dependent protein kinase (PKA) (CHEMBL2094138) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Isoquinoline-pyridine-based protein kinase B/Akt antagonists: SAR and in vivo antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.28 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL207544 | — | — | 1 | 9.00 |
| CHEMBL383264 | — | — | 1 | 8.68 |
| CHEMBL378963 | — | — | 1 | 8.30 |
| CHEMBL210390 | — | — | 1 | 8.10 |
| CHEMBL210246 | — | — | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL207544 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL383264 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL378963 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL210390 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL210246 | — | IC50 | = | 48.0 | nM | 7.32 |