Assay Detail
Binding
CHEMBL861328
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Inhibition of ERK2 at 5 uM ATP
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Isoquinoline-pyridine-based protein kinase B/Akt antagonists: SAR and in vivo antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.24 | 6.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL383264 | — | — | 1 | 6.04 |
| CHEMBL210390 | — | — | 1 | 5.92 |
| CHEMBL207544 | — | — | 1 | 4.57 |
| CHEMBL378963 | — | — | 1 | 4.43 |
| CHEMBL210246 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL383264 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL210390 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL207544 | — | IC50 | = | 27200.0 | nM | 4.57 |
| CHEMBL378963 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL210246 | — | IC50 | - | — | - |