Assay Detail
Functional
CHEMBL861332
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MiaPaCa2 cells by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Isoquinoline-pyridine-based protein kinase B/Akt antagonists: SAR and in vivo antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.72 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210390 | — | — | 1 | 7.00 |
| CHEMBL383264 | — | — | 1 | 6.23 |
| CHEMBL210246 | — | — | 1 | 5.50 |
| CHEMBL207544 | — | — | 1 | 4.97 |
| CHEMBL378963 | — | — | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210390 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL383264 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL210246 | — | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL207544 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL378963 | — | IC50 | = | 13300.0 | nM | 4.88 |