Assay Detail
Functional
CHEMBL861403
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Cytotoxicity against HEK293 cells transfected with recombinant AOR by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Investigating the role of stereochemistry in the activity of anticancer acylfulvenes: synthesis, reductase-mediated bioactivation, and cellular toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.36 | 7.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118218 | IROFULVEN | 3.0 | 1 | 7.26 |
| CHEMBL121987 | ACYLFULVENE | — | 1 | 7.02 |
| CHEMBL380919 | — | — | 1 | 5.85 |
| CHEMBL205439 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118218 | IROFULVEN | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL121987 | ACYLFULVENE | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL380919 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL205439 | — | IC50 | = | 5000.0 | nM | 5.30 |