Assay Detail
Functional
CHEMBL861415
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Cytotoxicity against doxorubicin-resistant K562 cell line by MTS assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Syntheses and biological activities of 3'-azido disaccharide analogues of daunorubicin against drug-resistant leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.63 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL202882 | — | — | 1 | 6.54 |
| CHEMBL201477 | — | — | 1 | 6.00 |
| CHEMBL203594 | — | — | 1 | 5.79 |
| CHEMBL206165 | — | — | 1 | 5.71 |
| CHEMBL202812 | — | — | 1 | 5.26 |
| CHEMBL383654 | — | — | 1 | 5.20 |
| CHEMBL381485 | — | — | 1 | 4.92 |
| CHEMBL1563 | DAUNORUBICIN HYDROCHLORIDE | 4.0 | 1 | - |
| CHEMBL383543 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL202882 | — | IC50 | = | 289.0 | nM | 6.54 |
| CHEMBL201477 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL203594 | — | IC50 | = | 1628.0 | nM | 5.79 |
| CHEMBL206165 | — | IC50 | = | 1926.0 | nM | 5.71 |
| CHEMBL202812 | — | IC50 | = | 5437.0 | nM | 5.26 |
| CHEMBL383654 | — | IC50 | = | 6388.0 | nM | 5.20 |
| CHEMBL381485 | — | IC50 | = | 12070.0 | nM | 4.92 |
| CHEMBL1563 | DAUNORUBICIN HYDROCHLORIDE | IC50 | > | 5000.0 | nM | - |
| CHEMBL383543 | — | IC50 | - | — | - |