Assay Detail
Functional
CHEMBL861473
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Antiproliferative activity against human pancreatic tumor cell line AsPC1
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ASPC1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.03 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184948 | — | — | 1 | 6.54 |
| CHEMBL120862 | — | — | 1 | 6.48 |
| CHEMBL120634 | — | — | 1 | 6.45 |
| CHEMBL200735 | — | — | 1 | 6.37 |
| CHEMBL120077 | — | — | 1 | 6.23 |
| CHEMBL432219 | — | — | 1 | 5.67 |
| CHEMBL331760 | — | — | 1 | 5.35 |
| CHEMBL121161 | — | — | 1 | 5.17 |
| CHEMBL371949 | — | — | 1 | - |
| CHEMBL371910 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184948 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL120862 | — | IC50 | = | 331.0 | nM | 6.48 |
| CHEMBL120634 | — | IC50 | = | 355.0 | nM | 6.45 |
| CHEMBL200735 | — | IC50 | = | 427.0 | nM | 6.37 |
| CHEMBL120077 | — | IC50 | = | 592.0 | nM | 6.23 |
| CHEMBL432219 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL331760 | — | IC50 | = | 4450.0 | nM | 5.35 |
| CHEMBL121161 | — | IC50 | = | 6820.0 | nM | 5.17 |
| CHEMBL371949 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL371910 | — | IC50 | > | 10000.0 | nM | - |