Assay Detail
Binding
CHEMBL861559
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Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 47 | 7.28 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268439 | — | — | 1 | 8.70 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 8.52 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 8.10 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 8.05 |
| CHEMBL73962 | BENZOLAMIDE | — | 1 | 8.05 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 8.00 |
| CHEMBL360356 | — | — | 1 | 7.92 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.85 |
| CHEMBL206295 | — | — | 1 | 7.82 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.82 |
| CHEMBL206657 | — | — | 1 | 7.75 |
| CHEMBL6753 | — | — | 1 | 7.72 |
| CHEMBL6685 | — | — | 1 | 7.52 |
| CHEMBL6633 | — | — | 1 | 7.48 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 7.46 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.42 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 7.40 |
| CHEMBL6724 | — | — | 1 | 7.40 |
| CHEMBL266026 | — | — | 1 | 7.34 |
| CHEMBL7146 | — | — | 1 | 7.30 |
| CHEMBL6853 | — | — | 1 | 7.22 |
| CHEMBL265674 | — | — | 1 | 7.22 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | — | 1 | 7.20 |
| CHEMBL268177 | — | — | 1 | 7.16 |
| CHEMBL266240 | — | — | 1 | 7.12 |
| CHEMBL6919 | — | — | 1 | 7.10 |
| CHEMBL204049 | — | — | 1 | 7.03 |
| CHEMBL204954 | — | — | 1 | 6.98 |
| CHEMBL7092 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268439 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL73962 | BENZOLAMIDE | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL360356 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL206295 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL77517 | INDISULAM | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL206657 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL6753 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL6685 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL6633 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL26 | SULPIRIDE | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL6724 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL266026 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL7146 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL6853 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL265674 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL268177 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL266240 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL6919 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL204049 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL204954 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL7092 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL203498 | — | Ki | = | 119.0 | nM | 6.92 |
| CHEMBL204077 | — | Ki | = | 123.0 | nM | 6.91 |
| CHEMBL6784 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL176495 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL381544 | — | Ki | = | 127.0 | nM | 6.90 |
| CHEMBL414 | CARZENIDE | Ki | = | 133.0 | nM | 6.88 |
| CHEMBL425044 | — | Ki | = | 133.0 | nM | 6.88 |
| CHEMBL7087 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL419 | MAFENIDE | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL206261 | — | Ki | = | 203.0 | nM | 6.69 |
| CHEMBL203112 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL204326 | — | Ki | = | 241.0 | nM | 6.62 |
| CHEMBL6705 | — | Ki | = | 295.0 | nM | 6.53 |
| CHEMBL7204 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL203534 | — | Ki | = | 354.0 | nM | 6.45 |