Assay Detail
Functional
CHEMBL861673
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of anti-CD3 antibody-induced IL2 production in human jurkat T cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery and SAR of 2-amino-5-[(thiomethyl)aryl]thiazoles as potent and selective Itk inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.63 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL381296 | — | — | 1 | 6.16 |
| CHEMBL382362 | — | — | 1 | 6.16 |
| CHEMBL381367 | — | — | 1 | 5.70 |
| CHEMBL383129 | — | — | 1 | 5.66 |
| CHEMBL208255 | — | — | 1 | 5.62 |
| CHEMBL204418 | — | — | 1 | 5.24 |
| CHEMBL207329 | — | — | 1 | 4.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL381296 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL382362 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL381367 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL383129 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL208255 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL204418 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL207329 | — | IC50 | = | 13500.0 | nM | 4.87 |