Assay Detail
Functional
CHEMBL861701
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Antiproliferative activity against human K562 cell line expressing Bcr-Abl
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.79 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL379687 | — | — | 1 | 5.22 |
| CHEMBL208098 | — | — | 1 | 5.10 |
| CHEMBL207244 | — | — | 1 | 5.10 |
| CHEMBL83527 | PTEROSTILBENE | 2.0 | 1 | 5.00 |
| CHEMBL296411 | TRISMETHOXYRESVERATROL | — | 1 | 5.00 |
| CHEMBL206919 | — | — | 1 | 5.00 |
| CHEMBL207240 | — | — | 1 | 4.85 |
| CHEMBL381164 | — | — | 1 | 4.85 |
| CHEMBL206633 | — | — | 1 | 4.80 |
| CHEMBL381734 | — | — | 1 | 4.75 |
| CHEMBL427392 | — | — | 1 | 4.70 |
| CHEMBL207941 | — | — | 1 | 4.70 |
| CHEMBL197892 | — | — | 1 | 4.70 |
| CHEMBL383273 | — | — | 1 | 4.64 |
| CHEMBL206049 | — | — | 1 | 4.62 |
| CHEMBL175736 | — | — | 1 | 4.58 |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 4.55 |
| CHEMBL207903 | — | — | 1 | 4.46 |
| CHEMBL362997 | — | — | 1 | 4.38 |
| CHEMBL207826 | — | — | 1 | - |
| CHEMBL194888 | — | — | 1 | - |
| CHEMBL207989 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL379687 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL208098 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL207244 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL83527 | PTEROSTILBENE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL296411 | TRISMETHOXYRESVERATROL | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL206919 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL207240 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL381164 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL206633 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL381734 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL427392 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL207941 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL197892 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL383273 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL206049 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL175736 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL165 | RESVERATROL | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL207903 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL362997 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL207826 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL194888 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL207989 | — | IC50 | > | 100000.0 | nM | - |