Assay Detail
Binding
CHEMBL861745
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiroperidol from cloned human dopamine receptor D3 expressed in CHO cells
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and binding affinities of potential positron emission tomography (PET) ligands for visualization of brain dopamine D3 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 7.14 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL196476 | — | — | 1 | 9.89 |
| CHEMBL201270 | — | — | 1 | 8.32 |
| CHEMBL201551 | — | — | 1 | 7.83 |
| CHEMBL199859 | — | — | 1 | 7.71 |
| CHEMBL199836 | — | — | 1 | 7.67 |
| CHEMBL199329 | — | — | 1 | 7.65 |
| CHEMBL203302 | — | — | 1 | 7.62 |
| CHEMBL201698 | — | — | 1 | 7.59 |
| CHEMBL197660 | — | — | 1 | 7.42 |
| CHEMBL424667 | — | — | 1 | 7.23 |
| CHEMBL126780 | — | — | 1 | 7.22 |
| CHEMBL199498 | — | — | 1 | 7.11 |
| CHEMBL372308 | — | — | 1 | 7.07 |
| CHEMBL198404 | — | — | 1 | 7.01 |
| CHEMBL201027 | — | — | 1 | 6.99 |
| CHEMBL200024 | — | — | 1 | 6.93 |
| CHEMBL202713 | — | — | 1 | 6.90 |
| CHEMBL199746 | — | — | 1 | 6.66 |
| CHEMBL201326 | — | — | 1 | 6.58 |
| CHEMBL197762 | — | — | 1 | 5.94 |
| CHEMBL426834 | — | — | 1 | 5.89 |
| CHEMBL199480 | — | — | 1 | 5.84 |
| CHEMBL435939 | — | — | 1 | 5.26 |
| CHEMBL202762 | — | — | 1 | - |
| CHEMBL200243 | — | — | 1 | - |
| CHEMBL201275 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL196476 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL201270 | — | Ki | = | 4.79 | nM | 8.32 |
| CHEMBL201551 | — | Ki | = | 14.7 | nM | 7.83 |
| CHEMBL199859 | — | Ki | = | 19.3 | nM | 7.71 |
| CHEMBL199836 | — | Ki | = | 21.4 | nM | 7.67 |
| CHEMBL199329 | — | Ki | = | 22.6 | nM | 7.65 |
| CHEMBL203302 | — | Ki | = | 23.9 | nM | 7.62 |
| CHEMBL201698 | — | Ki | = | 25.5 | nM | 7.59 |
| CHEMBL197660 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL424667 | — | Ki | = | 58.5 | nM | 7.23 |
| CHEMBL126780 | — | Ki | = | 60.1 | nM | 7.22 |
| CHEMBL199498 | — | Ki | = | 77.9 | nM | 7.11 |
| CHEMBL372308 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL198404 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL201027 | — | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL200024 | — | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL202713 | — | Ki | = | 127.0 | nM | 6.90 |
| CHEMBL199746 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL201326 | — | Ki | = | 262.0 | nM | 6.58 |
| CHEMBL197762 | — | Ki | = | 1140.0 | nM | 5.94 |
| CHEMBL426834 | — | Ki | = | 1285.0 | nM | 5.89 |
| CHEMBL199480 | — | Ki | = | 1440.0 | nM | 5.84 |
| CHEMBL435939 | — | Ki | = | 5539.0 | nM | 5.26 |
| CHEMBL202762 | — | Ki | > | 8500.0 | nM | - |
| CHEMBL200243 | — | Ki | > | 8500.0 | nM | - |
| CHEMBL201275 | — | Ki | > | 2700.0 | nM | - |