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Assay Detail

CHEMBL861818

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Functional
Antioxidant activity in unilamellar DOPC liposomes
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Subcellular Liposome
Confidence 3 — Cell-line / Tissue
Curated By Intermediate

Publication

Free radical scavenging and antioxidant activities of substituted hexahydropyridoindoles. Quantitative structure-activity relationships.
Rackova L, Snirc V, Majekova M, Majek P, Stefek M.
J Med Chem (2006) 49 : 2543 -2548
PubMed 16610797 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 4.99 5.53

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL204461 1 5.53
CHEMBL205832 1 5.49
CHEMBL203427 1 5.48
CHEMBL205581 1 5.36
CHEMBL204783 1 5.35
CHEMBL206533 1 5.29
CHEMBL204837 1 5.19
CHEMBL207930 1 5.16
CHEMBL440045 1 5.12
CHEMBL205827 1 4.90
CHEMBL380614 1 4.80
CHEMBL207758 1 4.71
CHEMBL205380 1 4.71
CHEMBL205296 1 4.70
CHEMBL206158 1 4.68
CHEMBL381339 1 4.66
CHEMBL479176 STOBADINE 1 4.60
CHEMBL204226 1 4.58
CHEMBL383635 1 4.48

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL204461 IC50 = 2951.21 nM 5.53
CHEMBL205832 IC50 = 3235.94 nM 5.49
CHEMBL203427 IC50 = 3311.31 nM 5.48
CHEMBL205581 IC50 = 4365.16 nM 5.36
CHEMBL204783 IC50 = 4466.84 nM 5.35
CHEMBL206533 IC50 = 5128.61 nM 5.29
CHEMBL204837 IC50 = 6456.54 nM 5.19
CHEMBL207930 IC50 = 6918.31 nM 5.16
CHEMBL440045 IC50 = 7585.78 nM 5.12
CHEMBL205827 IC50 = 12589.25 nM 4.90
CHEMBL380614 IC50 = 15848.93 nM 4.80
CHEMBL207758 IC50 = 19498.45 nM 4.71
CHEMBL205380 IC50 = 19498.45 nM 4.71
CHEMBL205296 IC50 = 19952.62 nM 4.70
CHEMBL206158 IC50 = 20892.96 nM 4.68
CHEMBL381339 IC50 = 21877.62 nM 4.66
CHEMBL479176 STOBADINE IC50 = 25118.86 nM 4.60
CHEMBL204226 IC50 = 26302.68 nM 4.58
CHEMBL383635 IC50 = 33113.11 nM 4.48