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Assay Detail

CHEMBL861854

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of LF by FRET assay
ChEMBL ↗
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bacillus anthracis
Confidence 9 — Direct single protein target
Curated By Expert

Target

Lethal factor (CHEMBL4372) ↗
Type SINGLE PROTEIN
Organism Bacillus anthracis

Publication

The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection.
Xiong Y, Wiltsie J, Woods A, Guo J, Pivnichny JV, Tang W, Bansal A, Cummings RT, Cunningham BR, Friedlander AM, Douglas CM, Salowe SP, Zaller DM, Scolnick EM, Schmatz DM, Bartizal K, Hermes JD, MacCoss M, Chapman KT.
Bioorg Med Chem Lett (2006) 16 : 964 -968
PubMed 16338135 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 50 6.46 7.43

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1161809 — — 1 7.43
CHEMBL1161813 — — 1 7.40
CHEMBL382675 — — 1 7.38
CHEMBL1161812 — — 1 7.32
CHEMBL204647 — — 1 7.30
CHEMBL203539 — — 1 7.29
CHEMBL204593 — — 1 7.27
CHEMBL1161811 — — 1 7.24
CHEMBL1161810 — — 1 7.23
CHEMBL202508 — — 1 7.19
CHEMBL204291 — — 1 7.19
CHEMBL437504 — — 1 7.17
CHEMBL203745 — — 1 7.17
CHEMBL202483 — — 1 7.16
CHEMBL1161814 — — 1 7.12
CHEMBL201564 — — 1 7.00
CHEMBL203848 — — 1 6.92
CHEMBL201675 — — 1 6.92
CHEMBL203703 — — 1 6.89
CHEMBL201868 — — 1 6.89
CHEMBL202623 — — 1 6.89
CHEMBL201968 — — 1 6.54
CHEMBL201674 — — 1 6.52
CHEMBL202104 — — 1 6.40
CHEMBL380714 — — 1 6.34
CHEMBL383156 — — 1 6.22
CHEMBL414858 — — 1 6.09
CHEMBL114272 — — 1 6.05
CHEMBL426112 — — 1 5.96
CHEMBL514138 CGS-27023A — 1 5.92

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1161809 — IC50 = 37.0 nM 7.43
CHEMBL1161813 — IC50 = 40.0 nM 7.40
CHEMBL382675 — IC50 = 42.0 nM 7.38
CHEMBL1161812 — IC50 = 48.0 nM 7.32
CHEMBL204647 — IC50 = 50.0 nM 7.30
CHEMBL203539 — IC50 = 51.0 nM 7.29
CHEMBL204593 — IC50 = 54.0 nM 7.27
CHEMBL1161811 — IC50 = 57.0 nM 7.24
CHEMBL1161810 — IC50 = 59.0 nM 7.23
CHEMBL202508 — IC50 = 65.0 nM 7.19
CHEMBL204291 — IC50 = 64.0 nM 7.19
CHEMBL437504 — IC50 = 67.0 nM 7.17
CHEMBL203745 — IC50 = 67.0 nM 7.17
CHEMBL202483 — IC50 = 70.0 nM 7.16
CHEMBL1161814 — IC50 = 75.0 nM 7.12
CHEMBL201564 — IC50 = 100.0 nM 7.00
CHEMBL203848 — IC50 = 120.0 nM 6.92
CHEMBL201675 — IC50 = 120.0 nM 6.92
CHEMBL203703 — IC50 = 130.0 nM 6.89
CHEMBL201868 — IC50 = 130.0 nM 6.89
CHEMBL202623 — IC50 = 130.0 nM 6.89
CHEMBL201968 — IC50 = 290.0 nM 6.54
CHEMBL201674 — IC50 = 300.0 nM 6.52
CHEMBL202104 — IC50 = 400.0 nM 6.40
CHEMBL380714 — IC50 = 460.0 nM 6.34
CHEMBL383156 — IC50 = 600.0 nM 6.22
CHEMBL414858 — IC50 = 810.0 nM 6.09
CHEMBL114272 — IC50 = 900.0 nM 6.05
CHEMBL426112 — IC50 = 1100.0 nM 5.96
CHEMBL514138 CGS-27023A IC50 = 1200.0 nM 5.92
CHEMBL202416 — IC50 = 1310.0 nM 5.88
CHEMBL201620 — IC50 = 1310.0 nM 5.88
CHEMBL203538 — IC50 = 1640.0 nM 5.79
CHEMBL203756 — IC50 = 2100.0 nM 5.68
CHEMBL202453 — IC50 = 2800.0 nM 5.55
CHEMBL201413 — IC50 = 3000.0 nM 5.52
CHEMBL437320 — IC50 = 3100.0 nM 5.51
CHEMBL204070 — IC50 = 5180.0 nM 5.29
CHEMBL201967 — IC50 = 6600.0 nM 5.18
CHEMBL204073 — IC50 = 11880.0 nM 4.92
CHEMBL204699 — IC50 = 16600.0 nM 4.78
CHEMBL201677 — IC50 = 19100.0 nM 4.72
CHEMBL202393 — IC50 > 40000.0 nM -
CHEMBL382396 — IC50 > 40000.0 nM -
CHEMBL432882 — IC50 > 40000.0 nM -
CHEMBL204807 — IC50 > 40000.0 nM -
CHEMBL203980 — IC50 > 40000.0 nM -
CHEMBL204806 — IC50 > 40000.0 nM -
CHEMBL439328 — IC50 > 40000.0 nM -
CHEMBL204316 — IC50 > 40000.0 nM -