Assay Detail
Binding
CHEMBL861855
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Inhibition of LF by MACK assay
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacillus anthracis |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 5.78 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL202623 | — | — | 1 | 6.92 |
| CHEMBL437504 | — | — | 1 | 6.89 |
| CHEMBL203539 | — | — | 1 | 6.89 |
| CHEMBL204291 | — | — | 1 | 6.77 |
| CHEMBL382675 | — | — | 1 | 6.72 |
| CHEMBL204593 | — | — | 1 | 6.68 |
| CHEMBL203745 | — | — | 1 | 6.64 |
| CHEMBL204647 | — | — | 1 | 6.43 |
| CHEMBL202483 | — | — | 1 | 6.39 |
| CHEMBL203848 | — | — | 1 | 6.35 |
| CHEMBL202508 | — | — | 1 | 6.34 |
| CHEMBL201564 | — | — | 1 | 6.31 |
| CHEMBL203703 | — | — | 1 | 6.17 |
| CHEMBL201675 | — | — | 1 | 6.14 |
| CHEMBL202104 | — | — | 1 | 5.89 |
| CHEMBL1161813 | — | — | 1 | 5.77 |
| CHEMBL201868 | — | — | 1 | 5.68 |
| CHEMBL201674 | — | — | 1 | 5.64 |
| CHEMBL380714 | — | — | 1 | 5.56 |
| CHEMBL1161814 | — | — | 1 | 5.55 |
| CHEMBL201968 | — | — | 1 | 5.52 |
| CHEMBL1161812 | — | — | 1 | 5.46 |
| CHEMBL383156 | — | — | 1 | 5.43 |
| CHEMBL202416 | — | — | 1 | 5.19 |
| CHEMBL114272 | — | — | 1 | 5.14 |
| CHEMBL1161810 | — | — | 1 | 5.13 |
| CHEMBL1161809 | — | — | 1 | 5.13 |
| CHEMBL426112 | — | — | 1 | 5.11 |
| CHEMBL1161811 | — | — | 1 | 5.06 |
| CHEMBL437320 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL202623 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL437504 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL203539 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL204291 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL382675 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL204593 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL203745 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL204647 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL202483 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL203848 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL202508 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL201564 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL203703 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL201675 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL202104 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL1161813 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL201868 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL201674 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL380714 | — | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL1161814 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL201968 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1161812 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL383156 | — | IC50 | = | 3740.0 | nM | 5.43 |
| CHEMBL202416 | — | IC50 | = | 6450.0 | nM | 5.19 |
| CHEMBL114272 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL1161809 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL1161810 | — | IC50 | = | 7470.0 | nM | 5.13 |
| CHEMBL426112 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL1161811 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL437320 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL414858 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL202453 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL201413 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL203510 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL204073 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL204070 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL202393 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL204316 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL432882 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL382396 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL201967 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL204807 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL203538 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL203980 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL204806 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL439328 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL204699 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL201620 | — | IC50 | > | 20000.0 | nM | - |