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Assay Detail

CHEMBL861867

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of MMP14
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Matrix metalloproteinase-14 (CHEMBL3869)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection.
Xiong Y, Wiltsie J, Woods A, Guo J, Pivnichny JV, Tang W, Bansal A, Cummings RT, Cunningham BR, Friedlander AM, Douglas CM, Salowe SP, Zaller DM, Scolnick EM, Schmatz DM, Bartizal K, Hermes JD, MacCoss M, Chapman KT.
Bioorg Med Chem Lett (2006) 16 : 964 -968
PubMed 16338135 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.19 5.19

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL204593 1 5.19

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL204593 IC50 = 6500.0 nM 5.19