Assay Detail
Binding
CHEMBL861926
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Inhibition of Aurora A kinase activity
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.45 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL201297 | — | — | 1 | 9.00 |
| CHEMBL202567 | — | — | 1 | 9.00 |
| CHEMBL201197 | — | — | 1 | 8.70 |
| CHEMBL373013 | — | — | 1 | 8.30 |
| CHEMBL201655 | — | — | 1 | 8.22 |
| CHEMBL382054 | — | — | 1 | 7.92 |
| CHEMBL201654 | — | — | 1 | 7.37 |
| CHEMBL202026 | — | — | 1 | 7.26 |
| CHEMBL383448 | — | — | 1 | 6.97 |
| CHEMBL201263 | — | — | 1 | 6.96 |
| CHEMBL424850 | — | — | 1 | 6.80 |
| CHEMBL203039 | — | — | 1 | 6.34 |
| CHEMBL202502 | — | — | 1 | 6.33 |
| CHEMBL203422 | — | — | 1 | 6.32 |
| CHEMBL382804 | — | — | 1 | 6.24 |
| CHEMBL202370 | — | — | 1 | - |
| CHEMBL202241 | — | — | 1 | - |
| CHEMBL380478 | — | — | 1 | - |
| CHEMBL201953 | — | — | 1 | - |
| CHEMBL202198 | — | — | 1 | - |
| CHEMBL377289 | — | — | 1 | - |
| CHEMBL381721 | — | — | 1 | - |
| CHEMBL201307 | — | — | 1 | - |
| CHEMBL202593 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL201297 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL202567 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL201197 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL373013 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL201655 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL382054 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL201654 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL202026 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL383448 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL201263 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL424850 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL203039 | — | IC50 | = | 452.0 | nM | 6.34 |
| CHEMBL202502 | — | IC50 | = | 472.0 | nM | 6.33 |
| CHEMBL203422 | — | IC50 | = | 483.0 | nM | 6.32 |
| CHEMBL382804 | — | IC50 | = | 578.0 | nM | 6.24 |
| CHEMBL202370 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL202241 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL380478 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL201953 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL202198 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL377289 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL381721 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL201307 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL202593 | — | IC50 | < | 1.0 | nM | - |