Assay Detail
Functional
CHEMBL861932
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Growth inhibition in human breast cancer SKBr3 cell line using SRB
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-BR-3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.43 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200001 | — | — | 1 | 7.35 |
| CHEMBL200102 | PU-H71 | 2.0 | 1 | 7.30 |
| CHEMBL372962 | — | — | 1 | 7.05 |
| CHEMBL377482 | — | — | 1 | 7.05 |
| CHEMBL383189 | — | — | 1 | 6.85 |
| CHEMBL199283 | — | — | 1 | 6.67 |
| CHEMBL201683 | — | — | 1 | 6.60 |
| CHEMBL365159 | — | — | 1 | 6.52 |
| CHEMBL199505 | — | — | 1 | 4.69 |
| CHEMBL372791 | — | — | 1 | 4.26 |
| CHEMBL202777 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200001 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL200102 | PU-H71 | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL372962 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL377482 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL383189 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL199283 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL201683 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL365159 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL199505 | — | IC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL372791 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL202777 | — | IC50 | > | 50000.0 | nM | - |