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Assay Detail

CHEMBL861965

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of PKA
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

cAMP-dependent protein kinase (PKA) (CHEMBL2094138)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies.
Morwick T, Berry A, Brickwood J, Cardozo M, Catron K, DeTuri M, Emeigh J, Homon C, Hrapchak M, Jacober S, Jakes S, Kaplita P, Kelly TA, Ksiazek J, Liuzzi M, Magolda R, Mao C, Marshall D, McNeil D, Prokopowicz A, Sarko C, Scouten E, Sledziona C, Sun S, Watrous J, Wu JP, Cywin CL.
J Med Chem (2006) 49 : 2898 -2908
PubMed 16686533 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 4.57 4.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL377085 1 4.57

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL377085 IC50 = 27000.0 nM 4.57