Assay Detail
Functional
CHEMBL862039
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Inhibition of phosphorylation of histone H3 in human SW620 cells
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW-620 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.88 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL201197 | — | — | 1 | 9.00 |
| CHEMBL381721 | — | — | 1 | 8.70 |
| CHEMBL380478 | — | — | 1 | 8.40 |
| CHEMBL201307 | — | — | 1 | 8.30 |
| CHEMBL201297 | — | — | 1 | 8.00 |
| CHEMBL202593 | — | — | 1 | 7.72 |
| CHEMBL377289 | — | — | 1 | 7.70 |
| CHEMBL373013 | — | — | 1 | 7.10 |
| CHEMBL382804 | — | — | 1 | 6.70 |
| CHEMBL202485 | — | — | 1 | 6.70 |
| CHEMBL201953 | — | — | 1 | 6.40 |
| CHEMBL424850 | — | — | 1 | 6.40 |
| CHEMBL202567 | — | — | 1 | 6.22 |
| CHEMBL203422 | — | — | 1 | 6.22 |
| CHEMBL382054 | — | — | 1 | 6.10 |
| CHEMBL383448 | — | — | 1 | 6.00 |
| CHEMBL202502 | — | — | 1 | 6.00 |
| CHEMBL201654 | — | — | 1 | 5.96 |
| CHEMBL201655 | — | — | 1 | 5.72 |
| CHEMBL202026 | — | — | 1 | 5.64 |
| CHEMBL201263 | — | — | 1 | 5.55 |
| CHEMBL202370 | — | — | 1 | - |
| CHEMBL202241 | — | — | 1 | - |
| CHEMBL203039 | — | — | 1 | - |
| CHEMBL202198 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL201197 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL381721 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL380478 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL201307 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL201297 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL202593 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL377289 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL373013 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL382804 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL202485 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL201953 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL424850 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL202567 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL203422 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL382054 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL383448 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL202502 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL201654 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL201655 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL202026 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL201263 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL202370 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL202241 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL203039 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL202198 | — | IC50 | < | 1.0 | nM | - |