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Assay Detail

CHEMBL862098

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to recombinant human adenosine A2B receptor
ChEMBL ↗
163
Total Activities
163
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Adenosine receptor A2b (CHEMBL255) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design, synthesis, and structure-activity relationships of 1-,3-,8-, and 9-substituted-9-deazaxanthines at the human A2B adenosine receptor.
Carotti A, Cadavid MI, Centeno NB, Esteve C, Loza MI, Martinez A, Nieto R, Raviña E, Sanz F, Segarra V, Sotelo E, Stefanachi A, Vidal B.
J Med Chem (2006) 49 : 282 -299
PubMed 16392813 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 146 7.64 8.82
pKi 17 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL16677 — — 1 8.82
CHEMBL370588 — — 1 8.81
CHEMBL432664 — — 1 8.72
CHEMBL273807 — — 1 8.70
CHEMBL278039 — — 1 8.67
CHEMBL201145 — — 1 8.66
CHEMBL16929 — — 1 8.65
CHEMBL17003 — — 1 8.62
CHEMBL370378 — — 1 8.58
CHEMBL199446 — — 1 8.52
CHEMBL382764 — — 1 8.50
CHEMBL201773 — — 1 8.50
CHEMBL203037 — — 1 8.50
CHEMBL275605 — — 1 8.50
CHEMBL380847 — — 1 8.49
CHEMBL201281 — — 1 8.48
CHEMBL201750 — — 1 8.46
CHEMBL439868 — — 1 8.45
CHEMBL382135 — — 1 8.42
CHEMBL199486 — — 1 8.41
CHEMBL201028 — — 1 8.39
CHEMBL199862 — — 1 8.33
CHEMBL381091 — — 1 8.32
CHEMBL199611 — — 1 8.32
CHEMBL203305 — — 1 8.31
CHEMBL202767 — — 1 8.29
CHEMBL202766 — — 1 8.29
CHEMBL372148 — — 1 8.28
CHEMBL201127 — — 1 8.25
CHEMBL200052 — — 1 8.23

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL16677 — Ki = 1.514 nM 8.82
CHEMBL370588 — Ki = 1.549 nM 8.81
CHEMBL432664 — Ki = 1.905 nM 8.72
CHEMBL273807 — Ki = 1.995 nM 8.70
CHEMBL278039 — Ki = 2.138 nM 8.67
CHEMBL201145 — Ki = 2.188 nM 8.66
CHEMBL16929 — Ki = 2.239 nM 8.65
CHEMBL17003 — Ki = 2.399 nM 8.62
CHEMBL370378 — Ki = 2.63 nM 8.58
CHEMBL199446 — Ki = 3.02 nM 8.52
CHEMBL275605 — Ki = 3.162 nM 8.50
CHEMBL201773 — Ki = 3.162 nM 8.50
CHEMBL203037 — Ki = 3.162 nM 8.50
CHEMBL382764 — Ki = 3.162 nM 8.50
CHEMBL380847 — Ki = 3.236 nM 8.49
CHEMBL201281 — Ki = 3.311 nM 8.48
CHEMBL201750 — Ki = 3.467 nM 8.46
CHEMBL439868 — Ki = 3.548 nM 8.45
CHEMBL382135 — Ki = 3.802 nM 8.42
CHEMBL199486 — Ki = 3.89 nM 8.41
CHEMBL201028 — Ki = 4.074 nM 8.39
CHEMBL199862 — Ki = 4.677 nM 8.33
CHEMBL199611 — Ki = 4.786 nM 8.32
CHEMBL381091 — Ki = 4.786 nM 8.32
CHEMBL203305 — Ki = 4.898 nM 8.31
CHEMBL202767 — Ki = 5.129 nM 8.29
CHEMBL202766 — Ki = 5.129 nM 8.29
CHEMBL372148 — Ki = 5.248 nM 8.28
CHEMBL201127 — Ki = 5.623 nM 8.25
CHEMBL200052 — Ki = 5.888 nM 8.23
CHEMBL201493 — Ki = 6.026 nM 8.22
CHEMBL381214 — Ki = 6.918 nM 8.16
CHEMBL201239 — Ki = 6.918 nM 8.16
CHEMBL203413 — Ki = 7.762 nM 8.11
CHEMBL201293 — Ki = 7.762 nM 8.11
CHEMBL201008 — Ki = 7.762 nM 8.11
CHEMBL201749 — Ki = 7.943 nM 8.10
CHEMBL275427 — Ki = 7.943 nM 8.10
CHEMBL201157 — Ki = 7.943 nM 8.10
CHEMBL201128 — Ki = 8.913 nM 8.05
CHEMBL377485 — Ki = 8.913 nM 8.05
CHEMBL202665 — Ki = 9.333 nM 8.03
CHEMBL381538 — Ki = 9.55 nM 8.02
CHEMBL198338 — Ki = 9.772 nM 8.01
CHEMBL379688 — Ki = 10.72 nM 7.97
CHEMBL201594 — Ki = 10.96 nM 7.96
CHEMBL201721 — Ki = 10.96 nM 7.96
CHEMBL381540 — Ki = 11.22 nM 7.95
CHEMBL383638 — Ki = 11.75 nM 7.93
CHEMBL202358 — Ki = 12.02 nM 7.92