Assay Detail
Functional
CHEMBL862161
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Cytotoxicity against human HeLa cells by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of 7-phenyl-6,9-dihydro-3H-pyrrolo[3,2-f]quinolin-9-ones: a new class of antimitotic agents devoid of aromatase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.79 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 8.30 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.10 |
| CHEMBL236555 | — | — | 1 | 6.16 |
| CHEMBL206175 | — | — | 1 | 6.16 |
| CHEMBL379229 | — | — | 1 | 5.30 |
| CHEMBL203847 | — | — | 1 | 5.30 |
| CHEMBL204144 | — | — | 1 | 5.22 |
| CHEMBL380828 | — | — | 1 | 5.22 |
| CHEMBL204143 | — | — | 1 | 5.16 |
| CHEMBL204771 | — | — | 1 | 5.10 |
| CHEMBL203514 | — | — | 1 | 4.82 |
| CHEMBL381126 | — | — | 1 | 4.60 |
| CHEMBL204766 | — | — | 1 | - |
| CHEMBL205825 | — | — | 1 | - |
| CHEMBL204001 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL236555 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL206175 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL379229 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL203847 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL204144 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL380828 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL204143 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL204771 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL203514 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL381126 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL204766 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL205825 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL204001 | — | IC50 | > | 50000.0 | nM | - |