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Assay Detail

CHEMBL862170

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Functional
Antiproliferative activity against U937 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type U-937
Confidence 1 — Organism
Curated By Expert

Target

U-937 (CHEMBL612794)
Type CELL-LINE
Organism Homo sapiens

Publication

Design and synthesis of 3-substituted benzamide derivatives as Bcr-Abl kinase inhibitors.
Asaki T, Sugiyama Y, Hamamoto T, Higashioka M, Umehara M, Naito H, Niwa T.
Bioorg Med Chem Lett (2006) 16 : 1421 -1425
PubMed 16332440 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.10 5.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL203343 1 5.40
CHEMBL205723 1 5.30
CHEMBL383010 1 5.30
CHEMBL203071 1 5.22
CHEMBL205409 1 5.10
CHEMBL206034 1 5.05
CHEMBL382605 1 5.05
CHEMBL206834 BAFETINIB 2.0 1 5.00
CHEMBL941 IMATINIB 4.0 1 4.85
CHEMBL383710 1 4.70
CHEMBL206319 1 -
CHEMBL383711 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL203343 IC50 = 4000.0 nM 5.40
CHEMBL205723 IC50 = 5000.0 nM 5.30
CHEMBL383010 IC50 = 5000.0 nM 5.30
CHEMBL203071 IC50 = 6000.0 nM 5.22
CHEMBL205409 IC50 = 8000.0 nM 5.10
CHEMBL206034 IC50 = 9000.0 nM 5.05
CHEMBL382605 IC50 = 9000.0 nM 5.05
CHEMBL206834 BAFETINIB IC50 = 10000.0 nM 5.00
CHEMBL941 IMATINIB IC50 = 14000.0 nM 4.85
CHEMBL383710 IC50 = 20000.0 nM 4.70
CHEMBL206319 IC50 > 100000.0 nM -
CHEMBL383711 IC50 > 100000.0 nM -