Assay Detail
Binding
CHEMBL862243
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against VEGFR2 kinase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Naphthofuroquinone derivatives: inhibition of receptor tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.10 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL78257 | TYRPHOSTIN 51 | — | 1 | 5.37 |
| CHEMBL200976 | — | — | 1 | 5.34 |
| CHEMBL202244 | — | — | 1 | 5.26 |
| CHEMBL202162 | — | — | 1 | 4.90 |
| CHEMBL201865 | — | — | 1 | 4.89 |
| CHEMBL383030 | — | — | 1 | 4.81 |
| CHEMBL201840 | — | — | 1 | - |
| CHEMBL202216 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL78257 | TYRPHOSTIN 51 | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL200976 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL202244 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL202162 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL201865 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL383030 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL201840 | — | IC50 | - | — | - | |
| CHEMBL202216 | — | IC50 | - | — | - |