Assay Detail
Binding
CHEMBL862313
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Inhibition of chk2 kinase
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Serine/threonine-protein kinase Chk2 (CHEMBL2527) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel non-benzimidazole chk2 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.50 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL179583 | — | — | 1 | 7.80 |
| CHEMBL178971 | — | — | 1 | 7.26 |
| CHEMBL206609 | — | — | 1 | 7.11 |
| CHEMBL208463 | — | — | 1 | 6.88 |
| CHEMBL367390 | — | — | 1 | 6.19 |
| CHEMBL205906 | — | — | 1 | 5.81 |
| CHEMBL377597 | — | — | 1 | 5.70 |
| CHEMBL204930 | — | — | 1 | 5.24 |
| CHEMBL205905 | — | — | 1 | - |
| CHEMBL382588 | — | — | 1 | - |
| CHEMBL204929 | — | — | 1 | - |
| CHEMBL202669 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL179583 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL178971 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL206609 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL208463 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL367390 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL205906 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL377597 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL204930 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL205905 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL382588 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL204929 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL202669 | — | IC50 | > | 10000.0 | nM | - |