Assay Detail
Binding
CHEMBL862402
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]AVP from human V2 receptor transfected in LV2 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | LV2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pyridobenzodiazepines: a novel class of orally active, vasopressin V2 receptor selective agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.54 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL363910 | — | — | 1 | 7.10 |
| CHEMBL202447 | — | — | 1 | 7.04 |
| CHEMBL203513 | — | — | 1 | 6.74 |
| CHEMBL203739 | — | — | 1 | 6.53 |
| CHEMBL381763 | — | — | 1 | 6.41 |
| CHEMBL380733 | — | — | 1 | 6.38 |
| CHEMBL205013 | — | — | 1 | 6.32 |
| CHEMBL201889 | — | — | 1 | 6.31 |
| CHEMBL202106 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL363910 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL202447 | — | IC50 | = | 91.5 | nM | 7.04 |
| CHEMBL203513 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL203739 | — | IC50 | = | 296.0 | nM | 6.53 |
| CHEMBL381763 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL380733 | — | IC50 | = | 413.0 | nM | 6.38 |
| CHEMBL205013 | — | IC50 | = | 475.0 | nM | 6.32 |
| CHEMBL201889 | — | IC50 | = | 493.0 | nM | 6.31 |
| CHEMBL202106 | — | IC50 | = | 933.0 | nM | 6.03 |