Assay Detail
Binding
CHEMBL862448
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Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPA
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1b |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
RNA-directed RNA polymerase (CHEMBL4296320) ↗| Type | SINGLE PROTEIN |
| Organism | Hepacivirus hominis |
Publication
Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: from benzimidazole to indole scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.77 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL386508 | — | — | 1 | 7.80 |
| CHEMBL214864 | — | — | 1 | 7.68 |
| CHEMBL383960 | — | — | 1 | 7.60 |
| CHEMBL425693 | — | — | 1 | 7.52 |
| CHEMBL216000 | — | — | 1 | 7.52 |
| CHEMBL215329 | — | — | 1 | 7.36 |
| CHEMBL368884 | — | — | 1 | 7.30 |
| CHEMBL216863 | — | — | 1 | 7.29 |
| CHEMBL387405 | — | — | 1 | 7.12 |
| CHEMBL384453 | — | — | 1 | 7.11 |
| CHEMBL263976 | — | — | 1 | 7.10 |
| CHEMBL384144 | — | — | 1 | 7.09 |
| CHEMBL215233 | — | — | 1 | 7.05 |
| CHEMBL1789968 | — | — | 1 | 6.82 |
| CHEMBL215089 | — | — | 1 | 6.75 |
| CHEMBL214031 | — | — | 1 | 6.64 |
| CHEMBL214595 | — | — | 1 | 6.54 |
| CHEMBL384028 | — | — | 1 | 6.47 |
| CHEMBL213819 | — | — | 1 | 6.32 |
| CHEMBL387310 | — | — | 1 | 6.09 |
| CHEMBL175177 | — | — | 1 | 5.96 |
| CHEMBL214600 | — | — | 1 | 5.66 |
| CHEMBL174683 | — | — | 1 | 5.57 |
| CHEMBL361434 | — | — | 1 | 5.51 |
| CHEMBL216032 | — | — | 1 | 5.28 |
| CHEMBL425788 | — | — | 1 | - |
| CHEMBL384169 | — | — | 1 | - |
| CHEMBL217360 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL386508 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL214864 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL383960 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL425693 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL216000 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL215329 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL368884 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL216863 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL387405 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL384453 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL263976 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL384144 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL215233 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1789968 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL215089 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL214031 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL214595 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL384028 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL213819 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL387310 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL175177 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL214600 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL174683 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL361434 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL216032 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL425788 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL384169 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL217360 | — | IC50 | > | 100000.0 | nM | - |