Assay Detail
Binding
CHEMBL862516
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Inhibitory activity against TACE
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Disintegrin and metalloproteinase domain-containing protein 17 (CHEMBL3706) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Conversion of potent MMP inhibitors into selective TACE inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.32 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL203160 | — | — | 1 | 8.43 |
| CHEMBL204048 | — | — | 1 | 8.23 |
| CHEMBL379469 | — | — | 1 | 8.08 |
| CHEMBL203972 | — | — | 1 | 6.82 |
| CHEMBL204549 | — | — | 1 | 6.32 |
| CHEMBL204495 | — | — | 1 | 6.05 |
| CHEMBL100570 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL203160 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL204048 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL379469 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL203972 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL204549 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL204495 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL100570 | — | IC50 | > | 1000.0 | nM | - |