Assay Detail
Binding
CHEMBL862550
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against HCV 1b BK NS5B deltaC55-R158K mutant RNA polymerase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1b |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
RNA-directed RNA polymerase (CHEMBL4296320) ↗| Type | SINGLE PROTEIN |
| Organism | Hepacivirus hominis |
Publication
2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.96 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL206518 | — | — | 1 | 6.05 |
| CHEMBL382383 | — | — | 1 | 4.80 |
| CHEMBL181653 | — | — | 1 | 4.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL206518 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL382383 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL181653 | — | IC50 | = | 92000.0 | nM | 4.04 |