Assay Detail
Binding
CHEMBL862677
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against PIM1
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Serine/threonine-protein kinase pim-1 (CHEMBL2147) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.38 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7463 | GF-109203 | — | 1 | 7.57 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 7.37 |
| CHEMBL200528 | — | — | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7463 | GF-109203 | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL50 | QUERCETIN | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL200528 | — | IC50 | = | 61.0 | nM | 7.21 |