Assay Detail
Binding
CHEMBL862690
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Inhibition of MAO-B in baboon liver mitochondria
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Papio |
| Tissue | Liver |
| Subcellular | Mitochondria |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis, structural reassignment, and biological activity of type B MAO inhibitors based on the 5H-indeno[1,2-c]pyridazin-5-one core.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.71 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL209413 | — | — | 1 | 10.00 |
| CHEMBL125520 | — | — | 1 | 7.42 |
| CHEMBL348961 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL209413 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL125520 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL348961 | — | IC50 | - | — | - |