Assay Detail
Functional
CHEMBL862762
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TNF-alpha-stimulated expression of VCAM1 in HUVEC cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 7 — Homologous single protein target |
| Curated By | Expert |
Target
Inhibitor of NF-kappa-B kinase (IKK) (CHEMBL2111328) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.06 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200106 | — | — | 1 | 6.70 |
| CHEMBL200027 | — | — | 1 | 6.52 |
| CHEMBL200229 | — | — | 1 | 6.40 |
| CHEMBL200462 | — | — | 1 | 6.30 |
| CHEMBL200832 | — | — | 1 | 6.30 |
| CHEMBL371543 | — | — | 1 | 6.22 |
| CHEMBL382752 | — | — | 1 | 5.70 |
| CHEMBL200946 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200106 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL200027 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL200229 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL200462 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL200832 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL371543 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL382752 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL200946 | — | IC50 | = | 50000.0 | nM | 4.30 |