Assay Detail
Functional
CHEMBL862764
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Inhibition of IFN-gamma-stimulated expression of HLA-DR
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.64 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL382752 | — | — | 1 | 6.60 |
| CHEMBL200832 | — | — | 1 | 6.30 |
| CHEMBL200462 | — | — | 1 | 5.70 |
| CHEMBL200027 | — | — | 1 | 5.70 |
| CHEMBL200229 | — | — | 1 | 5.70 |
| CHEMBL200106 | — | — | 1 | 5.60 |
| CHEMBL371543 | — | — | 1 | 5.52 |
| CHEMBL200946 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL382752 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL200832 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL200462 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL200027 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL200229 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL200106 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL371543 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL200946 | — | IC50 | = | 100000.0 | nM | 4.00 |