Assay Detail
Binding
CHEMBL862789
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Binding affinity to MMP8
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Matrix metalloproteinase target family landscape: a chemometrical approach to ligand selectivity based on protein binding site analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.10 | 8.60 |
| Ki | 1 | 7.77 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL115774 | — | — | 1 | 8.60 |
| CHEMBL373261 | — | — | 1 | 8.00 |
| CHEMBL381189 | — | — | 1 | 7.77 |
| CHEMBL200274 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL115774 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL373261 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL381189 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL200274 | — | IC50 | = | 20.0 | nM | 7.70 |