Assay Detail
Binding
CHEMBL862798
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against DNA methyl transferase in leukemic NALM6 cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NALM-6 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
DNA (cytosine-5)-methyltransferase 1 (CHEMBL1993) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of two novel, small-molecule inhibitors of DNA methylation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.15 | 4.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL383475 | — | — | 1 | 4.30 |
| CHEMBL382617 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL383475 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL382617 | — | IC50 | = | 100000.0 | nM | 4.00 |