Assay Detail
Binding
CHEMBL862800
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Inhibition of recombinant CpG methylase M.SssI
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Spiroplasma monobiae |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Orphan methyltransferase M.SssI (CHEMBL4373) ↗| Type | SINGLE PROTEIN |
| Organism | Spiroplasma monobiae |
Publication
Discovery of two novel, small-molecule inhibitors of DNA methylation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.31 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL382617 | — | — | 1 | 6.40 |
| CHEMBL383475 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL382617 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL383475 | — | IC50 | = | 600.0 | nM | 6.22 |