Assay Detail
Binding
CHEMBL862914
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Inhibition of HIV1 integrase strand transfer activity
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
From ligand to complexes: inhibition of human immunodeficiency virus type 1 integrase by beta-diketo acid metal complexes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.92 | 6.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL421353 | — | — | 1 | 6.27 |
| CHEMBL208722 | — | — | 1 | 4.32 |
| CHEMBL16326 | — | — | 1 | 4.16 |
| CHEMBL16633 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL421353 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL208722 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL16326 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL16633 | — | IC50 | > | 333000.0 | nM | - |