Assay Detail
Binding
CHEMBL862979
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Inhibitory activity against human PNMT
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Phenylethanolamine N-methyltransferase (CHEMBL4617) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibitors of phenylethanolamine N-methyltransferase devoid of alpha2-adrenoceptor affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 5.94 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287837 | — | — | 1 | 8.51 |
| CHEMBL200375 | — | — | 1 | 7.77 |
| CHEMBL41647 | — | — | 1 | 7.28 |
| CHEMBL59719 | — | — | 1 | 7.14 |
| CHEMBL26828 | — | — | 1 | 7.03 |
| CHEMBL26717 | — | — | 1 | 6.55 |
| CHEMBL197019 | — | — | 1 | 6.34 |
| CHEMBL437699 | — | — | 1 | 6.32 |
| CHEMBL439864 | — | — | 1 | 6.31 |
| CHEMBL371898 | — | — | 1 | 6.30 |
| CHEMBL370794 | — | — | 1 | 6.03 |
| CHEMBL198896 | — | — | 1 | 6.01 |
| CHEMBL196970 | — | — | 1 | 6.00 |
| CHEMBL359205 | — | — | 1 | 5.92 |
| CHEMBL197380 | — | — | 1 | 5.72 |
| CHEMBL371084 | — | — | 1 | 5.72 |
| CHEMBL200910 | — | — | 1 | 5.72 |
| CHEMBL112351 | — | — | 1 | 5.64 |
| CHEMBL112964 | — | — | 1 | 5.50 |
| CHEMBL196770 | — | — | 1 | 5.38 |
| CHEMBL342322 | — | — | 1 | 5.36 |
| CHEMBL200563 | — | — | 1 | 5.36 |
| CHEMBL198733 | — | — | 1 | 5.34 |
| CHEMBL200560 | — | — | 1 | 5.10 |
| CHEMBL112038 | — | — | 1 | 4.68 |
| CHEMBL444793 | — | — | 1 | 4.64 |
| CHEMBL112357 | — | — | 1 | 4.39 |
| CHEMBL199008 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287837 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL200375 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL41647 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL59719 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL26828 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL26717 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL197019 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL437699 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL439864 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL371898 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL370794 | — | Ki | = | 940.0 | nM | 6.03 |
| CHEMBL198896 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL196970 | — | Ki | = | 990.0 | nM | 6.00 |
| CHEMBL359205 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL197380 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL371084 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL200910 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL112351 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL112964 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL196770 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL342322 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL200563 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL198733 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL200560 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL112038 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL444793 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL112357 | — | Ki | = | 41000.0 | nM | 4.39 |
| CHEMBL199008 | — | Ki | = | 60000.0 | nM | 4.22 |