Assay Detail
Binding
CHEMBL862987
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against HIV1 protease
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.47 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL371085 | — | — | 1 | 8.92 |
| CHEMBL200296 | — | — | 1 | 8.68 |
| CHEMBL198734 | — | — | 1 | 8.42 |
| CHEMBL434190 | — | — | 1 | 8.21 |
| CHEMBL370853 | — | — | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL371085 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL200296 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL198734 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL434190 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL370853 | — | IC50 | = | 7.9 | nM | 8.10 |