Assay Detail
Functional
CHEMBL862990
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Cytotoxicity against human Burkitt lymphoma, DAUDI cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Daudi |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.67 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL198075 | CRYPTOPLEURINE | — | 1 | 8.70 |
| CHEMBL197867 | — | — | 1 | 5.04 |
| CHEMBL199706 | — | — | 1 | 4.92 |
| CHEMBL200016 | — | — | 1 | 4.87 |
| CHEMBL199705 | — | — | 1 | 4.80 |
| CHEMBL199292 | — | — | 1 | - |
| CHEMBL381672 | — | — | 1 | - |
| CHEMBL197918 | — | — | 1 | - |
| CHEMBL199594 | — | — | 1 | - |
| CHEMBL197819 | — | — | 1 | - |
| CHEMBL380570 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL198075 | CRYPTOPLEURINE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL197867 | — | IC50 | = | 9080.0 | nM | 5.04 |
| CHEMBL199706 | — | IC50 | = | 12040.0 | nM | 4.92 |
| CHEMBL200016 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL199705 | — | IC50 | = | 15710.0 | nM | 4.80 |
| CHEMBL199292 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL381672 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL197918 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL199594 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL197819 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL380570 | — | IC50 | - | — | - |