Assay Detail
Binding
CHEMBL863032
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV integrase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Triketoacid inhibitors of HIV-integrase: a new chemotype useful for probing the integrase pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.38 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL211028 | — | — | 1 | 8.00 |
| CHEMBL50605 | — | — | 1 | 7.70 |
| CHEMBL108760 | — | — | 1 | 7.10 |
| CHEMBL211014 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL211028 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL50605 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL108760 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL211014 | — | IC50 | = | 200.0 | nM | 6.70 |