Assay Detail
Functional
CHEMBL863239
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Antiproliferative activity against human breast cancer MCF7 cell line in presence of 0.003 nM estradiol
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Estrogen receptor ligands. Part 14: application of novel antagonist side chains to existing platforms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 9.52 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL197495 | — | — | 1 | 10.15 |
| CHEMBL437695 | — | — | 1 | 10.10 |
| CHEMBL372808 | — | — | 1 | 10.00 |
| CHEMBL328190 | LASOFOXIFENE | 4.0 | 1 | 10.00 |
| CHEMBL182402 | — | — | 1 | 9.70 |
| CHEMBL198803 | — | — | 1 | 9.70 |
| CHEMBL180300 | — | — | 1 | 9.52 |
| CHEMBL198914 | — | — | 1 | 9.52 |
| CHEMBL46740 | BAZEDOXIFENE | 4.0 | 1 | 9.40 |
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 9.10 |
| CHEMBL183584 | — | — | 1 | 9.05 |
| CHEMBL372337 | — | — | 1 | 9.00 |
| CHEMBL362623 | — | — | 1 | 8.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL197495 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL437695 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL372808 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL328190 | LASOFOXIFENE | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL182402 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL198803 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL180300 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL198914 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL46740 | BAZEDOXIFENE | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL81 | RALOXIFENE | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL183584 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL372337 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL362623 | — | IC50 | = | 3.3 | nM | 8.48 |