Assay Detail
Functional
CHEMBL863246
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity at mouse CCR1 in CHO-K1 cells
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.32 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL372807 | — | — | 1 | 8.40 |
| CHEMBL200242 | — | — | 1 | 7.40 |
| CHEMBL200629 | — | — | 1 | 7.30 |
| CHEMBL200680 | — | — | 1 | 7.30 |
| CHEMBL196860 | — | — | 1 | 6.52 |
| CHEMBL198852 | — | — | 1 | 6.35 |
| CHEMBL370596 | — | — | 1 | 6.30 |
| CHEMBL198949 | — | — | 1 | 6.24 |
| CHEMBL197375 | — | — | 1 | 6.22 |
| CHEMBL199412 | — | — | 1 | 6.00 |
| CHEMBL535607 | BX 471 | 2.0 | 1 | 5.82 |
| CHEMBL370162 | — | — | 1 | 5.52 |
| CHEMBL200794 | — | — | 1 | 5.52 |
| CHEMBL198966 | — | — | 1 | 5.32 |
| CHEMBL197345 | — | — | 1 | 4.64 |
| CHEMBL371248 | — | — | 1 | - |
| CHEMBL380568 | — | — | 1 | - |
| CHEMBL381446 | — | — | 1 | - |
| CHEMBL381223 | — | — | 1 | - |
| CHEMBL196908 | — | — | 1 | - |
| CHEMBL370447 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL372807 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL200242 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL200629 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL200680 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL196860 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL198852 | — | IC50 | = | 448.0 | nM | 6.35 |
| CHEMBL370596 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL198949 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL197375 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL199412 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL535607 | BX 471 | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL370162 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL200794 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL198966 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL197345 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL371248 | — | IC50 | - | — | - | |
| CHEMBL380568 | — | IC50 | - | — | - | |
| CHEMBL381446 | — | IC50 | - | — | - | |
| CHEMBL381223 | — | IC50 | - | — | - | |
| CHEMBL196908 | — | IC50 | - | — | - | |
| CHEMBL370447 | — | IC50 | - | — | - |