Assay Detail
Binding
CHEMBL863256
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of COX2 in human whole blood
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Blood |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Racemic and chiral sulfoxides as potential prodrugs of the COX-2 inhibitors Vioxx and Arcoxia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.64 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122 | ROFECOXIB | 4.0 | 1 | 6.12 |
| CHEMBL416146 | ETORICOXIB | 4.0 | 1 | 6.09 |
| CHEMBL3084325 | — | — | 1 | 5.68 |
| CHEMBL2096829 | — | — | 1 | 5.46 |
| CHEMBL383092 | — | — | 1 | 5.43 |
| CHEMBL426856 | — | — | 1 | 5.38 |
| CHEMBL207594 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122 | ROFECOXIB | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL416146 | ETORICOXIB | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL3084325 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL2096829 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL383092 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL426856 | — | IC50 | = | 4220.0 | nM | 5.38 |
| CHEMBL207594 | — | IC50 | = | 4930.0 | nM | 5.31 |