Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL863286

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity towards human SGLT2 expressed in CHO-K1 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO-K1
Confidence 9 — Direct single protein target
Curated By Expert

Target

Sodium/glucose cotransporter 2 (CHEMBL3884)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Heteroaryl-O-glucosides as novel sodium glucose co-transporter 2 inhibitors. Part 1.
Zhang X, Urbanski M, Patel M, Zeck RE, Cox GG, Bian H, Conway BR, Pat Beavers M, Rybczynski PJ, Demarest KT.
Bioorg Med Chem Lett (2005) 15 : 5202 -5206
PubMed 16198559 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 6.80 7.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL183937 1 7.96
CHEMBL200438 1 7.62
CHEMBL200250 1 7.41
CHEMBL434175 1 7.17
CHEMBL200394 1 6.79
CHEMBL200236 1 6.42
CHEMBL382293 1 6.41
CHEMBL382302 1 6.34
CHEMBL371448 1 6.31
CHEMBL382319 1 6.27
CHEMBL200608 1 6.12

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL183937 IC50 = 11.0 nM 7.96
CHEMBL200438 IC50 = 24.0 nM 7.62
CHEMBL200250 IC50 = 39.0 nM 7.41
CHEMBL434175 IC50 = 67.0 nM 7.17
CHEMBL200394 IC50 = 163.0 nM 6.79
CHEMBL200236 IC50 = 380.0 nM 6.42
CHEMBL382293 IC50 = 394.0 nM 6.41
CHEMBL382302 IC50 = 458.0 nM 6.34
CHEMBL371448 IC50 = 491.0 nM 6.31
CHEMBL382319 IC50 = 532.0 nM 6.27
CHEMBL200608 IC50 = 754.0 nM 6.12