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Assay Detail

CHEMBL863350

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against bovine cathepsin L using Z-Phe-Arg-NHMec substrate
ChEMBL ↗
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Procathepsin L (CHEMBL2113) ↗
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Interaction of papain-like cysteine proteases with dipeptide-derived nitriles.
Löser R, Schilling K, Dimmig E, Gütschow M.
J Med Chem (2005) 48 : 7688 -7707
PubMed 16302809 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 48 5.79 7.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL200521 — — 1 7.66
CHEMBL200557 — — 1 6.92
CHEMBL344174 — — 1 6.75
CHEMBL371466 — — 1 6.64
CHEMBL371499 — — 1 6.57
CHEMBL383781 — — 1 6.50
CHEMBL200558 — — 1 6.47
CHEMBL381191 — — 1 6.46
CHEMBL371893 — — 1 6.40
CHEMBL380560 — — 1 6.37
CHEMBL200549 — — 1 6.33
CHEMBL200374 — — 1 6.28
CHEMBL200235 — — 1 6.26
CHEMBL200724 — — 1 6.20
CHEMBL200836 — — 1 6.19
CHEMBL372154 — — 1 6.16
CHEMBL200161 — — 1 6.12
CHEMBL370188 — — 1 5.96
CHEMBL200427 — — 1 5.96
CHEMBL200160 — — 1 5.92
CHEMBL200577 — — 1 5.80
CHEMBL200285 — — 1 5.77
CHEMBL200181 — — 1 5.64
CHEMBL200576 — — 1 5.60
CHEMBL200004 — — 1 5.55
CHEMBL200057 — — 1 5.35
CHEMBL197113 — — 1 5.31
CHEMBL197181 — — 1 5.24
CHEMBL198570 — — 1 5.03
CHEMBL424669 — — 1 4.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL200521 — Ki = 22.0 nM 7.66
CHEMBL200557 — Ki = 120.0 nM 6.92
CHEMBL344174 — Ki = 180.0 nM 6.75
CHEMBL371466 — Ki = 230.0 nM 6.64
CHEMBL371499 — Ki = 270.0 nM 6.57
CHEMBL383781 — Ki = 320.0 nM 6.50
CHEMBL200558 — Ki = 340.0 nM 6.47
CHEMBL381191 — Ki = 350.0 nM 6.46
CHEMBL371893 — Ki = 400.0 nM 6.40
CHEMBL380560 — Ki = 430.0 nM 6.37
CHEMBL200549 — Ki = 470.0 nM 6.33
CHEMBL200374 — Ki = 520.0 nM 6.28
CHEMBL200235 — Ki = 550.0 nM 6.26
CHEMBL200724 — Ki = 630.0 nM 6.20
CHEMBL200836 — Ki = 640.0 nM 6.19
CHEMBL372154 — Ki = 700.0 nM 6.16
CHEMBL200161 — Ki = 750.0 nM 6.12
CHEMBL370188 — Ki = 1100.0 nM 5.96
CHEMBL200427 — Ki = 1100.0 nM 5.96
CHEMBL200160 — Ki = 1200.0 nM 5.92
CHEMBL200577 — Ki = 1600.0 nM 5.80
CHEMBL200285 — Ki = 1700.0 nM 5.77
CHEMBL200181 — Ki = 2300.0 nM 5.64
CHEMBL200576 — Ki = 2500.0 nM 5.60
CHEMBL200004 — Ki = 2800.0 nM 5.55
CHEMBL200057 — Ki = 4500.0 nM 5.35
CHEMBL197113 — Ki = 4900.0 nM 5.31
CHEMBL197181 — Ki = 5800.0 nM 5.24
CHEMBL198570 — Ki = 9400.0 nM 5.03
CHEMBL424669 — Ki = 14000.0 nM 4.85
CHEMBL383584 — Ki = 19000.0 nM 4.72
CHEMBL381847 — Ki = 19000.0 nM 4.72
CHEMBL383816 — Ki = 22000.0 nM 4.66
CHEMBL200338 — Ki = 25000.0 nM 4.60
CHEMBL200574 — Ki = 29000.0 nM 4.54
CHEMBL197130 — Ki = 33000.0 nM 4.48
CHEMBL371285 — Ki = 47000.0 nM 4.33
CHEMBL197975 — Ki > 1000000.0 nM -
CHEMBL381659 — Ki > 100000.0 nM -
CHEMBL200150 — Ki > 1000000.0 nM -
CHEMBL200005 — Ki > 1000000.0 nM -
CHEMBL197498 — Ki > 100000.0 nM -
CHEMBL200743 — Ki > 100000.0 nM -
CHEMBL200815 — Ki > 100000.0 nM -
CHEMBL200007 — Ki > 100000.0 nM -
CHEMBL200569 — Ki > 100000.0 nM -
CHEMBL200635 — Ki > 100000.0 nM -
CHEMBL200006 — Ki > 1000000.0 nM -