Assay Detail
Binding
CHEMBL863358
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Binding affinity to Hsp90 by fluorescent polarization assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Structure-based discovery of a new class of Hsp90 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.55 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414883 | RADICICOL | — | 1 | 6.82 |
| CHEMBL200628 | — | — | 1 | 6.22 |
| CHEMBL371915 | — | — | 1 | 6.16 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 5.90 |
| CHEMBL200702 | — | — | 1 | 5.66 |
| CHEMBL444355 | — | — | 1 | 5.48 |
| CHEMBL200200 | — | — | 1 | 5.21 |
| CHEMBL199218 | — | — | 1 | 5.18 |
| CHEMBL200939 | — | — | 1 | 5.06 |
| CHEMBL200600 | — | — | 1 | 4.82 |
| CHEMBL372769 | — | — | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414883 | RADICICOL | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL200628 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL371915 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL200702 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL444355 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL200200 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL199218 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL200939 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL200600 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL372769 | — | IC50 | = | 26400.0 | nM | 4.58 |