Assay Detail
Binding
CHEMBL863392
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Inhibitory activity against human FAS1
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.00 | 4.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL399043 | THIOLACTOMYCIN | — | 1 | 4.00 |
| CHEMBL322740 | RAC-THIOLACTOMYCIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL399043 | THIOLACTOMYCIN | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL322740 | RAC-THIOLACTOMYCIN | IC50 | = | 143000.0 | nM | - |