Assay Detail
Binding
CHEMBL863398
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Displacement of [125I]AB-MECA from human adenosine A3 receptor transfected in CHO cells
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-uronamides as highly potent and selective agonists at the human A3 adenosine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 39 | 7.31 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL201706 | — | — | 1 | 9.55 |
| CHEMBL200732 | — | — | 1 | 9.42 |
| CHEMBL203357 | — | — | 1 | 9.40 |
| CHEMBL200705 | — | — | 1 | 9.17 |
| CHEMBL200854 | — | — | 1 | 9.05 |
| CHEMBL201427 | — | — | 1 | 8.96 |
| CHEMBL201324 | — | — | 1 | 8.79 |
| CHEMBL370187 | — | — | 1 | 8.66 |
| CHEMBL200184 | — | — | 1 | 8.65 |
| CHEMBL200099 | — | — | 1 | 8.60 |
| CHEMBL199877 | — | — | 1 | 8.55 |
| CHEMBL202189 | — | — | 1 | 8.55 |
| CHEMBL370446 | — | — | 1 | 8.53 |
| CHEMBL200279 | — | — | 1 | 8.44 |
| CHEMBL381408 | — | — | 1 | 8.37 |
| CHEMBL381868 | — | — | 1 | 8.26 |
| CHEMBL200778 | — | — | 1 | 7.76 |
| CHEMBL200407 | — | — | 1 | 7.74 |
| CHEMBL200072 | — | — | 1 | 7.56 |
| CHEMBL199541 | — | — | 1 | 7.53 |
| CHEMBL200919 | — | — | 1 | 7.38 |
| CHEMBL199307 | — | — | 1 | 7.07 |
| CHEMBL199414 | — | — | 1 | 6.51 |
| CHEMBL200339 | — | — | 1 | 6.46 |
| CHEMBL200064 | — | — | 1 | 6.45 |
| CHEMBL440215 | — | — | 1 | 6.38 |
| CHEMBL199522 | — | — | 1 | 6.36 |
| CHEMBL409142 | — | — | 1 | 6.29 |
| CHEMBL371022 | — | — | 1 | 6.20 |
| CHEMBL372602 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL201706 | — | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL200732 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL203357 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL200705 | — | Ki | = | 0.67 | nM | 9.17 |
| CHEMBL200854 | — | Ki | = | 0.89 | nM | 9.05 |
| CHEMBL201427 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL201324 | — | Ki | = | 1.63 | nM | 8.79 |
| CHEMBL370187 | — | Ki | = | 2.18 | nM | 8.66 |
| CHEMBL200184 | — | Ki | = | 2.24 | nM | 8.65 |
| CHEMBL200099 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL202189 | — | Ki | = | 2.83 | nM | 8.55 |
| CHEMBL199877 | — | Ki | = | 2.82 | nM | 8.55 |
| CHEMBL370446 | — | Ki | = | 2.96 | nM | 8.53 |
| CHEMBL200279 | — | Ki | = | 3.64 | nM | 8.44 |
| CHEMBL381408 | — | Ki | = | 4.27 | nM | 8.37 |
| CHEMBL381868 | — | Ki | = | 5.56 | nM | 8.26 |
| CHEMBL200778 | — | Ki | = | 17.4 | nM | 7.76 |
| CHEMBL200407 | — | Ki | = | 18.2 | nM | 7.74 |
| CHEMBL200072 | — | Ki | = | 27.8 | nM | 7.56 |
| CHEMBL199541 | — | Ki | = | 29.7 | nM | 7.53 |
| CHEMBL200919 | — | Ki | = | 41.9 | nM | 7.38 |
| CHEMBL199307 | — | Ki | = | 85.6 | nM | 7.07 |
| CHEMBL199414 | — | Ki | = | 308.0 | nM | 6.51 |
| CHEMBL200339 | — | Ki | = | 343.0 | nM | 6.46 |
| CHEMBL200064 | — | Ki | = | 354.0 | nM | 6.45 |
| CHEMBL440215 | — | Ki | = | 415.0 | nM | 6.38 |
| CHEMBL199522 | — | Ki | = | 433.0 | nM | 6.36 |
| CHEMBL409142 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL371022 | — | Ki | = | 632.0 | nM | 6.20 |
| CHEMBL372602 | — | Ki | = | 878.0 | nM | 6.06 |
| CHEMBL380773 | — | Ki | = | 1440.0 | nM | 5.84 |
| CHEMBL200033 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL202923 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL412259 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL383283 | — | Ki | = | 3870.0 | nM | 5.41 |
| CHEMBL201934 | — | Ki | = | 4020.0 | nM | 5.40 |
| CHEMBL200332 | — | Ki | = | 4440.0 | nM | 5.35 |
| CHEMBL200372 | — | Ki | = | 7670.0 | nM | 5.12 |
| CHEMBL199413 | — | Ki | = | 49200.0 | nM | 4.31 |